Systematic Screening of Associations between Medication Use and Risk of Neurodegenerative Diseases Using a Mendelian Randomization Approach

Background: Systematically assessing the causal associations between medications and neurodegenerative diseases is significant in identifying disease etiology novel therapies. Here, we investigated putative 23 existing medication categories major (NDs), including Alzheimer’s (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). Methods: A two-sample mendelian randomization (MR) approach was conducted. Estimates were calculated using inverse-variance weighted (IVW) method as main model. sensitivity analysis a pleiotropy performed to identify potential violations. Results: Genetically predisposition antihypertensives (OR = 0.809, 95% CI 0.668–0.981, p 0.031), thyroid preparations 0.948, 0.909–0.988, 0.011), immunosuppressants 0.879, 0.789–0.979, 0.018) associated with decreased risk of AD. Genetic proxies for 0.934, 0.884–0.988, 0.017), 0.825, 0.699–0.973, 0.022), glucocorticoids 0.862, 0.756–0.983, 0.027) causally PD. determined antithrombotic agents 1.234, 1.042–1.461, 0.015), HMG CoA reductase inhibitors 1.085, 1.025–1.148, 0.005), salicylic acid derivatives 1.294, 1.078–1.553, 0.006) an increased ALS. Conclusions: We presented systematic view concerning NDs, which will promote discovery, drug repositioning patient management NDs.